ResultsĬompared with their wild-type littermates, the Arhgef10-depleted mice showed social interaction impairment, hyperactivity, and decreased depression-like and anxiety-like behavior. We generated Arhgef10 knockout mice as a model of ASD and characterized the social behavior and the biochemical changes in the brains of the knockout mice. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear. A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. One of the genes included in the deleted region is ARHGEF10. Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. Impaired social interaction is one of the essential features of autism spectrum disorder (ASD).
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